ACSL3 and ACSL4, Distinct Roles in Ferroptosis and Cancers

The long-chain fatty acyl CoA synthetase (ACSLs) family of enzymes contributes significantly to lipid metabolism and produces acyl-coenzyme A by catalyzing fatty acid oxidation. The dysregulation of ACSL3 and ACSL4, which belong to the five isoforms of ACSLs, plays a key role in cancer initiation, d...

Full description

Saved in:
Bibliographic Details
Published inCancers Vol. 14; no. 23; p. 5896
Main Authors Yang, Yufei, Zhu, Ting, Wang, Xu, Xiong, Fen, Hu, Zhangmin, Qiao, Xuehan, Yuan, Xiao, Wang, Deqiang
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 29.11.2022
MDPI
Subjects
Apoptosis
Cancer
Cancer therapies
Care and treatment
Cell death
Coenzyme A
Ferroptosis
Health aspects
Isoforms
Ligases
Lipid metabolism
Lipid peroxidation
Lipids
Metastases
Molecular modelling
Oxidation
Review
Tumors
China
ACSL4
cancer
ferroptosis
ACSL3
Online AccessGet full text

Cover

More Information
Summary:The long-chain fatty acyl CoA synthetase (ACSLs) family of enzymes contributes significantly to lipid metabolism and produces acyl-coenzyme A by catalyzing fatty acid oxidation. The dysregulation of ACSL3 and ACSL4, which belong to the five isoforms of ACSLs, plays a key role in cancer initiation, development, metastasis, and tumor immunity and may provide several possible therapeutic strategies. Moreover, ACSL3 and ACSL4 are crucial for ferroptosis, a non-apoptotic cell death triggered by the accumulation of membrane lipid peroxides due to iron overload. Here, we present a summary of the current knowledge on ACSL3 and ACSL4 and their functions in various cancers. Research on the molecular mechanisms involved in the regulation of ferroptosis is critical to developing targeted therapies for cancer.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
These authors contributed equally to this work.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14235896