The Mini-Addenbrooke's Cognitive Examination: A New Assessment Tool for Dementia

Background/Aims: We developed and validated the Mini-Addenbrooke's Cognitive Examination (M-ACE) in dementia patients. Comparisons were also made with the Mini Mental State Examination (MMSE). Method: The M-ACE was developed using Mokken scaling analysis in 117 dementia patients [behavioural va...

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Published inDementia and geriatric cognitive disorders Vol. 39; no. 1-2; pp. 1 - 11
Main Authors Hsieh, Sharpley, McGrory, Sarah, Leslie, Felicity, Dawson, Kate, Ahmed, Samrah, Butler, Chris R., Rowe, James B., Mioshi, Eneida, Hodges, John R.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2015
Subjects
Aged
Dementia
Dementia - classification
Dementia - diagnosis
Dementia - psychology
Diagnosis
Evaluation
Female
Humans
Male
Mental health screening
Methods
Middle Aged
Neuropsychological Tests
Old age cognition
Original
Original Research Article
Sensitivity and Specificity
Australia
United Kingdom
Frontotemporal dementia
Alzheimer's disease
Corticobasal degeneration
Cognitive screening test
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Summary:Background/Aims: We developed and validated the Mini-Addenbrooke's Cognitive Examination (M-ACE) in dementia patients. Comparisons were also made with the Mini Mental State Examination (MMSE). Method: The M-ACE was developed using Mokken scaling analysis in 117 dementia patients [behavioural variant frontotemporal dementia (bvFTD), n = 25; primary progressive aphasia (PPA), n = 49; Alzheimer's disease (AD), n = 34; corticobasal syndrome (CBS), n = 9] and validated in an independent sample of 164 dementia patients (bvFTD, n = 23; PPA, n = 82; AD, n = 38; CBS, n = 21) and 78 controls, who also completed the MMSE. Results: The M-ACE consists of 5 items with a maximum score of 30. Two cut-offs were identified: (1) ≤25/30 has both high sensitivity and specificity, and (2) ≤21/30 is almost certainly a score to have come from a dementia patient regardless of the clinical setting. The M-ACE is more sensitive than the MMSE and is less likely to have ceiling effects. Conclusion: The M-ACE is a brief and sensitive cognitive screening tool for dementia. Two cut-offs (25 or 21) are recommended. © 2014 S. Karger AG, Basel
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ISSN:1420-8008
1421-9824
1421-9824
DOI:10.1159/000366040