Mechanism of the Antipeptic Action of Anionic Carbohydrate and Its Clinical Application for the Treatment of Peptic Ulcer

• Published in: The Tohoku Journal of Experimental Medicine Vol. 103; no. 2; pp. 141 - 157
• Main Author: ISHIMORI, AKIRA
• Format: Journal Article
• Language: English
• Published: Japan Tohoku University Medical Press 01.01.1971
• Subjects: anionic carbohydrate; antipeptic action; Blood Proteins - analysis; Carbohydrates - pharmacology; Carbohydrates - therapeutic use; Chromatography, DEAE-Cellulose; Dextrans - pharmacology; Dextrans - therapeutic use; Electrophoresis; Gastric Juice - enzymology; Gastric Mucosa - analysis; Humans; Hydrogen-Ion Concentration; Immunoelectrophoresis; Molecular Weight; Pepsin A - analysis; Pepsin A - antagonists & inhibitors; peptic ulcer; Peptic Ulcer - drug therapy; Peptic Ulcer - metabolism; Protease Inhibitors; Sulfates - pharmacology; Sulfates - therapeutic use; Sulfur - analysis; Sulfur - pharmacology
• ISSN: 0040-8727; 1349-3329
• DOI: 10.1620/tjem.103.141

The antipeptic effects of various anionic carbohydrate preparations were found to vary depending on the source and molecular weight of carbohydrate, the types and the grades of esterification, and minerals attached to anionic groups. Dextran sulfate inhibits all proteases separated from gastric mucosa. The antipeptic effects are assumed to be due to the chemical binding of anionic carbohydrate not only with pepsin, but also with substrate proteins basing on the results obtained in both in vitro and electrophoretic experiments. Immunoelectrophoretic analysis revealed that the peptic ulcer-covering ‘white coating’ contains plasma proteins. These findings are thought to indicate that anionic carbohydrate can be used for the treatment of peptic ulcer. The significance of chemical binding of anionic carbohydrate to ‘white coating’ is stressed.