EFFICIENT PREPARATION OF 32-OXYGENATED LANOSTEROL DERIVATIVES

An efficient synthesis of 32-hydroxy- and 32-oxo-lanost-8-en-3β-ol (2 and 4) from the 8-ene-15-ketone 7 was described.

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 39; no. 6; pp. 1647 - 1648
Main Authors TAKANO, Yukiko, MORISAKI, Masuo
Format Journal Article
LanguageEnglish
Published TOKYO The Pharmaceutical Society of Japan 1991
Pharmaceutical Soc Japan
Maruzen
Subjects
14-demethylase
32-hydroxylanost-8-en-3β-ol
32-oxo-lanost-8-en-3β-ol
Alicyclic compounds, terpenoids, prostaglandins, steroids
antimycotic agent
benzyloxymethylation
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Exact sciences and technology
hypocholesterolemic agent
Life Sciences & Biomedicine
Organic chemistry
Pharmacology & Pharmacy
Physical Sciences
Preparations and properties
Science & Technology
Steroids
32-OXO-LANOST-8-EN-3-BETA-OL
HYPOCHOLESTEROLEMIC AGENT
BENZYLOXYMETHYLATION
ANTIMYCOTIC AGENT
32-HYDROXYLANOST-8-EN-3-BETA-OL
14-DEMETHYLASE
Steroid
Aliphatic compound
Triterpene
Secondary alcohol
Aldehyde
Allylic compound
Primary alcohol
Antilipemic agent
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Summary:An efficient synthesis of 32-hydroxy- and 32-oxo-lanost-8-en-3β-ol (2 and 4) from the 8-ene-15-ketone 7 was described.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.39.1647