Developmental hearing loss disrupts synaptic inhibition: implications for auditory processing

Hearing loss during development leads to central deficits that persist even after the restoration of peripheral function. One key class of deficits is due to changes in central inhibitory synapses, which play a fundamental role in all aspects of auditory processing. This review focuses on the anatom...

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Bibliographic Details
Published inFuture Neurology Vol. 4; no. 3; pp. 331 - 349
Main Authors Takesian, Anne E, Kotak, Vibhakar C, Sanes, Dan H
Format Journal Article Book Review
LanguageEnglish
Published England Future Medicine Ltd 01.05.2009
Subjects
Auditory cortex
Central nervous system diseases
Complications and side effects
deafness
development
excitability
frequency tuning
Health aspects
Hearing loss
inferior colliculus
LSO
MSO
Risk factors
sound localization
United States
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Summary:Hearing loss during development leads to central deficits that persist even after the restoration of peripheral function. One key class of deficits is due to changes in central inhibitory synapses, which play a fundamental role in all aspects of auditory processing. This review focuses on the anatomical and physiological alterations of inhibitory connections at several regions within the central auditory pathway following hearing loss. Such aberrant inhibitory synaptic function may be linked to deficits in encoding binaural and spectral cues. Understanding the cellular changes that occur at inhibitory synapses following hearing loss may provide specific loci that can be targeted to improve function.
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For reprint orders, please contact: reprints@futuremedicine.com
ISSN:1479-6708
1748-6971
DOI:10.2217/fnl.09.5