Functional role of CCL5/RANTES for HCC progression during chronic liver disease

• Published in: Journal of hepatology Vol. 66; no. 4; pp. 743 - 753
• Main Authors: Mohs, Antje, Kuttkat, Nadine, Reißing, Johanna, Zimmermann, Henning Wolfgang, Sonntag, Roland, Proudfoot, Amanda, Youssef, Sameh A, de Bruin, Alain, Cubero, Francisco Javier, Trautwein, Christian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2017; Elsevier Science Ltd
• Subjects: Angiogenesis; Animal models; Animals; Apoptosis; Bone marrow transplantation; Carcinogenesis; Carcinoma, Hepatocellular - etiology; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - immunology; CCR5 protein; CD11b antigen; CD4 antigen; CD45 antigen; CD8 antigen; Chemokine CCL5 - antagonists & inhibitors; Chemokine CCL5 - deficiency; Chemokine CCL5 - genetics; Chemokine CCL5 - metabolism; Clonal deletion; Disease Progression; Fibrosis; Fibrosis therapy; Gastroenterology and Hepatology; HCC; Hematopoiesis - immunology; Hepatitis, Chronic - complications; Hepatitis, Chronic - genetics; Hepatitis, Chronic - immunology; Hepatocellular carcinoma; Hepatocytes; Humans; Inflammation; Leukocytes (granulocytic); Ligands; Liver Cirrhosis - etiology; Liver Cirrhosis - immunology; Liver Cirrhosis - pathology; Liver diseases; Liver Neoplasms - etiology; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Liver Neoplasms, Experimental - etiology; Liver Neoplasms, Experimental - immunology; Lymphocytes T; Male; Medical treatment; Metastases; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; NFkB signaling; RANTES; Receptors, CCR5 - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Roles; Studies; Tumor necrosis factor-α; Tumors; HCC; Inflammation; Fibrosis therapy; NFkB signaling
• ISSN: 0168-8278; 1600-0641
• DOI: 10.1016/j.jhep.2016.12.011

Graphical abstract