Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids
Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpreta...
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| Published in | Cell stem cell Vol. 28; no. 5; pp. 816 - 832 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
06.05.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.
Lack of clear definitions and nomenclature for hepatic, pancreatic, and biliary organoids have hampered scientific communication and consistent interpretation. Through the consensus of experts in the field, Marsee et al. introduce an intuitive classification system for organoids and propose guidelines to promote the standardization and validation of future organoid systems. |
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| AbstractList | Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.
Lack of clear definitions and nomenclature for hepatic, pancreatic, and biliary organoids have hampered scientific communication and consistent interpretation. Through the consensus of experts in the field, Marsee et al. introduce an intuitive classification system for organoids and propose guidelines to promote the standardization and validation of future organoid systems. Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids. Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids. |
| Author | Forbes, Stuart Kamiya, Akihide Sancho-Bru, Pau Stange, Daniel Simons, Ben Ogawa, Shinichiro Cardinale, Vincenzo Andersson, Emma Spee, Bart Roos, Floris Gehart, Helmuth Rimland, Casey Tirnitz-Parker, Janina E.E. George, Gregory Chikada, Hiromi Peng, Weng Chuan Hu, Huili van der Laan, Luc J.W. Lancaster, Madeline Nuciforo, Sandro Onder, Tamer Tevfik Heim, Markus Boj, Sylvia Hannan, Nicholas Verstegen, Monique M.A. Huch, Meritxell Baptista, Pedro Man, Nancy de Koning, Eelco Roos, Floris J.M. Peltz, Gary Clevers, Hans Zaret, Kenneth van IJzendoorn, Sven van Boxtel, Ruben Soroka, Carol Forbes, Stuart J. Georgakopoulos, Nikitas Fuchs, Sabine Carpino, Guido Aloia, Luigi Boyer, James Hendriks, Delilah Grün, Dominic Artegiani, Benedetta Sato, Toshiro Lemaigre, Frédéric Saito, Yoshimasa LaRusso, Nicholas Lutolf, Matthias Broutier, Laura Kuijk, Ewart Prior, Nicole Braconi, Chiara Wang, Shuyong Lu, Wei-Yu Verstegen, Monique Yeoh, George Grappin-Botton, Anne Meneses, Andre van der Laan, Luc IJzermans, Jan Marsee, Ary Takebe, Takanori Schneeberger, Kerstin Strom, |
| AuthorAffiliation | HPB Organoid Consortium, ETH Zurich, Zurich, Switzerland |
| AuthorAffiliation_xml | – name: HPB Organoid Consortium, ETH Zurich, Zurich, Switzerland |
| Author_xml | – sequence: 1 givenname: Ary surname: Marsee fullname: Marsee, Ary organization: Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands – sequence: 2 givenname: Floris J.M. surname: Roos fullname: Roos, Floris J.M. organization: Department of Surgery, Erasmus MC-University Medical Center, Rotterdam, the Netherlands – sequence: 3 givenname: Monique M.A. surname: Verstegen fullname: Verstegen, Monique M.A. organization: Department of Surgery, Erasmus MC-University Medical Center, Rotterdam, the Netherlands – sequence: 4 givenname: Ary surname: Marsee fullname: Marsee, Ary – sequence: 5 givenname: Floris surname: Roos fullname: Roos, Floris – sequence: 6 givenname: Monique surname: Verstegen fullname: Verstegen, Monique – sequence: 7 givenname: Hans surname: Clevers fullname: Clevers, Hans – sequence: 8 givenname: Ludovic surname: Vallier fullname: Vallier, Ludovic – sequence: 9 givenname: Takanori surname: Takebe 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sequence: 62 givenname: Nicholas surname: Hannan fullname: Hannan, Nicholas – sequence: 63 givenname: Wei-Yu surname: Lu fullname: Lu, Wei-Yu – sequence: 64 givenname: Stephen surname: Strom fullname: Strom, Stephen – sequence: 65 givenname: Pau surname: Sancho-Bru fullname: Sancho-Bru, Pau – sequence: 66 givenname: Shinichiro surname: Ogawa fullname: Ogawa, Shinichiro – sequence: 67 givenname: Vincenzo surname: Corbo fullname: Corbo, Vincenzo – sequence: 68 givenname: Madeline surname: Lancaster fullname: Lancaster, Madeline – sequence: 69 givenname: Huili surname: Hu fullname: Hu, Huili – sequence: 70 givenname: Sabine surname: Fuchs fullname: Fuchs, Sabine – sequence: 71 givenname: Delilah surname: Hendriks fullname: Hendriks, Delilah – sequence: 72 givenname: Helmuth surname: Gehart fullname: Gehart, Helmuth organization: Institute for Molecular Health Sciences, ETH Zurich, Zurich, Switzerland – sequence: 73 givenname: Eelco surname: de Koning fullname: de Koning, Eelco organization: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, the Netherlands – sequence: 74 givenname: Frédéric surname: Lemaigre fullname: Lemaigre, Frédéric organization: Université Catholique de Louvain, de Duve Institute, Brussels, Belgium – sequence: 75 givenname: Stuart J. surname: Forbes fullname: Forbes, Stuart J. organization: MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, UK – sequence: 76 givenname: Weng Chuan surname: Peng fullname: Peng, Weng Chuan organization: Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands – sequence: 77 givenname: Meritxell surname: Huch fullname: Huch, Meritxell organization: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany – sequence: 78 givenname: Takanori surname: Takebe fullname: Takebe, Takanori organization: Division of Gastroenterology, Hepatology and Nutrition, Division of Developmental Biology, and Center 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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33961769$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:146648019$$DView record from Swedish Publication Index |
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| Keywords | epithelial organoid gallbladder multi-tissue organoid multi-organ organoid liver pancreas bile duct HPB tumor organoid Delphi method |
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