Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

• Published in: Cell stem cell Vol. 28; no. 5; pp. 816 - 832
• Main Authors: Marsee, Ary, Roos, Floris J.M., Verstegen, Monique M.A., Roos, Floris, Verstegen, Monique, Clevers, Hans, Vallier, Ludovic, Takebe, Takanori, Huch, Meritxell, Peng, Weng Chuan, Forbes, Stuart, Lemaigre, Frédéric, de Koning, Eelco, Gehart, Helmuth, van der Laan, Luc, Spee, Bart, Boj, Sylvia, Baptista, Pedro, Schneeberger, Kerstin, Soroka, Carol, Heim, Markus, Nuciforo, Sandro, Zaret, Kenneth, Saito, Yoshimasa, Lutolf, Matthias, Cardinale, Vincenzo, Simons, Ben, van IJzendoorn, Sven, Kamiya, Akihide, Chikada, Hiromi, Wang, Shuyong, Mun, Seon Ju, Son, Myung Jin, Onder, Tamer Tevfik, Boyer, James, Sato, Toshiro, Georgakopoulos, Nikitas, Meneses, Andre, Broutier, Laura, Boulter, Luke, Grün, Dominic, IJzermans, Jan, Artegiani, Benedetta, van Boxtel, Ruben, Kuijk, Ewart, Carpino, Guido, Peltz, Gary, Banales, Jesus, Man, Nancy, Aloia, Luigi, LaRusso, Nicholas, George, Gregory, Rimland, Casey, Yeoh, George, Grappin-Botton, Anne, Stange, Daniel, Prior, Nicole, Tirnitz-Parker, Janina E.E., Andersson, Emma, Braconi, Chiara, Hannan, Nicholas, Lu, Wei-Yu, Strom, Stephen, Sancho-Bru, Pau, Ogawa, Shinichiro, Corbo, Vincenzo, Lancaster, Madeline, Hu, Huili, Fuchs, Sabine, Hendriks, Delilah, Forbes, Stuart J., van der Laan, Luc J.W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.05.2021
• Subjects: bile duct; Consensus; Delphi method; epithelial organoid; gallbladder; HPB; Liver; Medicin och hälsovetenskap; multi-organ organoid; multi-tissue organoid; Organoids; Pancreas; tumor organoid; epithelial organoid; gallbladder; multi-tissue organoid; multi-organ organoid; liver; pancreas; bile duct; HPB; tumor organoid; Delphi method
• ISSN: 1934-5909; 1875-9777; 1875-9777
• DOI: 10.1016/j.stem.2021.04.005

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids. Lack of clear definitions and nomenclature for hepatic, pancreatic, and biliary organoids have hampered scientific communication and consistent interpretation. Through the consensus of experts in the field, Marsee et al. introduce an intuitive classification system for organoids and propose guidelines to promote the standardization and validation of future organoid systems.