Portal Vein Thrombosis as a Cause of Undetermined Thrombocytopenia with Liver Dysfunction in a Patient with Eosinophilic Granulomatosis with Polyangiitis

• Published in: Internal Medicine Vol. 62; no. 1; pp. 123 - 127
• Main Authors: Oka, Naoya, Yoshida, Yusuke, Sugimoto, Tomohiro, Yorishima, Ai, Masuda, Sho, Hirata, Shintaro
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2023; Japan Science and Technology Agency
• Subjects: Adult; Asthma; Case Report; Churg-Strauss Syndrome - complications; Churg-Strauss Syndrome - diagnosis; Churg-Strauss Syndrome - drug therapy; Computed tomography; eosinophilic granulomatosis with polyangiitis; Female; Glucocorticoids; Granulomatosis; Granulomatosis with Polyangiitis - complications; Granulomatosis with Polyangiitis - diagnosis; Humans; Internal medicine; Leukocytes (eosinophilic); Leukopenia; Liver Diseases; liver dysfunction; Portal vein; Portal Vein - diagnostic imaging; portal vein thrombosis; Thrombocytopenia; Thrombosis; Young Adult; eosinophilic granulomatosis with polyangiitis; liver dysfunction; portal vein thrombosis; thrombocytopenia
• ISSN: 0918-2918; 1349-7235; 1349-7235
• DOI: 10.2169/internalmedicine.9485-22

We herein report a 20-year-old woman who developed eosinophilic granulomatosis with polyangiitis (EGPA) and portal vein thrombosis (PVT). EGPA was diagnosed based on the patient's history of asthma, hypereosinophilia, and mononeuritis complex. Thrombocytopenia and liver dysfunction were observed, necessitating contrast-enhanced computed tomography (CECT), which revealed PVT. Her symptoms soon improved with glucocorticoids and anticoagulation therapy. As patients with EGPA often suffer from asthma, they can be hesitant to undergo CECT. However, if patients with EGPA show uncertain thrombocytopenia with liver dysfunction, a further evaluation using CECT is warranted to detect PVT.