The Current Status of Photodynamic Therapy in Cancer Treatment

Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic therapy (PDT), a non-invasive therapeutic approach, has attracted much attention. PDT exhibits outstanding performance in...

Full description

Saved in:
Bibliographic Details
Published inCancers Vol. 15; no. 3; p. 585
Main Authors Jiang, Wenqi, Liang, Mingkang, Lei, Qifang, Li, Guangzhi, Wu, Song
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 18.01.2023
MDPI
Subjects
Apoptosis
Autophagy
Blood vessels
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Efficiency
Energy
Forecasts and trends
Free radicals
Gene therapy
Hypoxia
Invasiveness
Lasers
Light
Light penetration
Localization
Metabolism
Methods
Oxidation
Oxidative stress
PDT
PDT-based combination therapy
Photochemotherapy
Photodynamic therapy
photosensitizer
Proteins
Radiation therapy
Reactive oxygen species
Review
Solid tumors
Tumors
China
United States > US
Japan
PDT
PDT-based combination therapy
photosensitizer
Online AccessGet full text

Cover

More Information
Summary:Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic therapy (PDT), a non-invasive therapeutic approach, has attracted much attention. PDT exhibits outstanding performance in cancer therapy, but some unavoidable disadvantages, including limited light penetration depth, poor tumor selectivity, as well as oxygen dependence, largely limit its therapeutic efficiency for solid tumors treatment. Thus, numerous strategies have gone into overcoming these obstacles, such as exploring new photosensitizers with higher photodynamic conversion efficiency, alleviating tumor hypoxia to fuel the generation of reactive oxygen species (ROS), designing tumor-targeted PS, and applying PDT-based combination strategies. In this review, we briefly summarized the PDT related tumor therapeutic approaches, which are mainly characterized by advanced PSs, these PSs have excellent conversion efficiency and additional refreshing features. We also briefly summarize PDT-based combination therapies with excellent therapeutic effects.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
These authors contributed equally to this work.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15030585