Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agents

[Display omitted] A new series of pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives were prepared by the multi-component cyclo-condensation reaction of 1-phenyl-3-(2-(tosyloxy)phenyl)propane-1,3-dione, N,N-dimethylformamide dimethyl acetal and hydrazine or hydroxylam...

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Published inArabian journal of chemistry Vol. 12; no. 8; pp. 2091 - 2097
Main Authors Kendre, Babasaheb V., Landge, Mahadev G., Bhusare, Sudhakar R.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.12.2019
Elsevier
Subjects
Anti-inflammatory
Benzodiazepine
Benzothiazepine
Benzoxazepine
Isoxazole
Pyrazole
Isoxazole
Anti-inflammatory
Pyrazole
Benzothiazepine
Benzodiazepine
Benzoxazepine
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Summary:[Display omitted] A new series of pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives were prepared by the multi-component cyclo-condensation reaction of 1-phenyl-3-(2-(tosyloxy)phenyl)propane-1,3-dione, N,N-dimethylformamide dimethyl acetal and hydrazine or hydroxylamine hydrochloride or 2-aminothiophenol or 2-aminophenol or benzene-1,2-diamine using μwave technique in aqueous media. All the synthesized compounds were evaluated for their anti-bacterial and antifungal activities. Some of the selected compounds were also screened for their anti-inflammatory activity.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2015.01.007