AN EFFICIENT SYNTHESIS OF (±)-EMETINE USING α, β-UNSATURATED LACTAM AS A MICHAEL ACCEPTOR

A new and simple synthesis of (±)-emetine uses α, β-unsaturated lactams (4__∼b__∼), (4__∼c__∼), and (4__∼e__∼) as new Michael acceptors.

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 34; no. 8; pp. 3530 - 3533
Main Authors Naito, Takeaki, Kojima, Noriko, Miyata, Okiko, Ninomiya, Ichiya
Format Journal Article
LanguageEnglish
Published TOKYO The Pharmaceutical Society of Japan 1986
Pharmaceutical Soc Japan
Maruzen
Subjects
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Life Sciences & Biomedicine
Michael reaction
Organic chemistry
Pharmacology & Pharmacy
Physical Sciences
Preparations and properties
Science & Technology
Michael addition
Lithium Compounds
Alkaloid
Angular nitrogen heterocycle
Nitrogen heterocycle
Lactam
Bicyclic compound
Racemate
Aromatic compound
Tricyclic compound
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Summary:A new and simple synthesis of (±)-emetine uses α, β-unsaturated lactams (4__∼b__∼), (4__∼c__∼), and (4__∼e__∼) as new Michael acceptors.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.34.3530