Combined Shear Wave Elastography and EU TIRADS in Differentiating Malignant and Benign Thyroid Nodules

• Published in: Cancers Vol. 14; no. 22; p. 5521
• Main Authors: Chambara, Nonhlanhla, Lo, Xina, Chow, Tom Chi Man, Lai, Carol Man Sze, Liu, Shirley Yuk Wah, Ying, Michael
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2022; MDPI
• Subjects: Accuracy; Benign; Biopsy; Cellular biology; Cytology; Diagnosis; Diagnosis, Ultrasonic; Differential diagnosis; Efficiency; Histopathology; Malignancy; Measurement techniques; Methods; Nodules; Patients; shear wave elastography; Surgery; Thyroid cancer; Thyroid Imaging and Reporting Data System (TIRADS); thyroid nodule; Tumors; Ultrasonic imaging; Ultrasound; China; Thyroid Imaging and Reporting Data System (TIRADS); thyroid nodule; ultrasound; shear wave elastography
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers14225521

Although multimodal ultrasound approaches have been suggested to potentially improve the diagnosis of thyroid cancer; the diagnostic utility of the combination of SWE and malignancy-risk stratification systems remains vague due to the lack of standardized criteria. The purpose of the study was to assess the diagnostic value of the combination of grey scale ultrasound assessment using EU TIRADS and shear wave elastography. 121 patients (126 nodules−81 benign; 45 malignant) underwent grey scale ultrasound and SWE imaging of nodules between 0.5 cm and 5 cm prior to biopsy and/or surgery. Nodules were analyzed based on size stratifications: <1 cm (n = 43); 1−2 cm (n = 52) and >2 cm (n = 31) and equivocal cytology status (n = 52), and diagnostic performance assessments were conducted. The combination of EU TIRADS with SWE using the SD parameter; maintained a high sensitivity and significantly improved the specificity of sole EU TIRADS for nodules 1−2 cm (SEN: 72.2% vs. 88.9%, p > 0.05; SPEC: 76.5% vs. 55.9%, p < 0.01) and >2 cm (SEN: 71.4% vs. 85.7%, p > 0.05; SPEC: 95.8% vs. 62.5%, p < 0.01). For cytologically-equivocal nodules; the combination with the SWE minimum parameter resulted in a significant reduction in sensitivity with increased specificity (SEN: 60% vs. 80%; SPEC: 83.4% vs. 37.8%; all p < 0.05). SWE in combination with EU TIRADS is diagnostically efficient in discriminating nodules > 1 cm but is not ideal for discriminating cytologically-equivocal nodules.