Induction of immunogenicity by live attenuated Leishmania donovani centrin deleted parasites in dogs

• Published in: Vaccine Vol. 31; no. 14; pp. 1785 - 1792
• Main Authors: Fiuza, Jacqueline Araújo, Santiago, Helton da Costa, Selvapandiyan, Angamuthu, Gannavaram, Sreenivas, Ricci, Natasha Delaqua, Bueno, Lilian Lacerda, Bartholomeu, Daniella Castanheira, Correa-Oliveira, Rodrigo, Nakhasi, Hira Lal, Fujiwara, Ricardo Toshio
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 03.04.2013; Elsevier
• Subjects: Allergy and Immunology; Animals; Applied microbiology; Attenuated parasite; B-Lymphocytes - cytology; B-Lymphocytes - immunology; Biological and medical sciences; Calcium-Binding Proteins - genetics; Canine visceral leishmaniasis; CD8-positive T-lymphocytes; Chromosomal Proteins, Non-Histone - genetics; Cytokines - immunology; dog diseases; Dog Diseases - immunology; Dog Diseases - parasitology; Dog Diseases - prevention & control; Dogs; drug resistance; Fundamental and applied biological sciences. Psychology; human diseases; Human protozoal diseases; immune response; immunoglobulin G; Infectious diseases; interferon-gamma; interleukin-4; Leishmania donovani; Leishmania donovani - genetics; Leishmania donovani - immunology; Leishmania infantum; Leishmaniasis Vaccines - administration & dosage; Leishmaniasis Vaccines - immunology; Leishmaniasis, Visceral - immunology; Leishmaniasis, Visceral - parasitology; Leishmaniasis, Visceral - veterinary; Leshmaniasis; Medical sciences; Microbiology; parasites; Parasitic diseases; Protozoal diseases; public health; recombinant vaccines; risk; secretion; seroprevalence; T-Lymphocytes - cytology; T-Lymphocytes - immunology; tumor necrosis factor-alpha; vaccination; Vaccine; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - immunology; Vaccines, Synthetic - immunology; visceral leishmaniasis; Middle East; South America; Southern European region; Vaccine; Attenuated parasite; Canine visceral leishmaniasis; Kinetoplastida; Fissipedia; Protozoa; Carnivora; Protozoal disease; Leishmania donovani; Kala azar; Leishmaniasis; Parasitosis; Infection; Vertebrata; Mammalia; Immunogenicity; Attenuated strain; Veterinary; Dog
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.01.048

Highlights ► We evaluate a centrin deleted parasite as vaccine in dogs. ► We compare with a commercially available recombinant vaccine. ► The vaccine was highly safe and immunogenic. ► The findings will contribute to the understanding of immunogenicity elicited by live attenuated vaccines.