Stem Cells from Deciduous Tooth Repair Mandibular Defect in Swine

Stem cells from human exfoliated deciduous teeth have been identified as a new post-natal stem cell population with multipotential differentiation capabilities, including regeneration of mineralized tissues in vivo. To examine the efficacy of utilizing these stem cells in regenerating orofacial bone...

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Published inJournal of dental research Vol. 88; no. 3; pp. 249 - 254
Main Authors Zheng, Y., Liu, Y., Zhang, C.M., Zhang, H.Y., Li, W.H., Shi, S., Le, A.D., Wang, S.L.
Format Journal Article
LanguageEnglish
Published United States SAGE Publications 01.03.2009
SAGE PUBLICATIONS, INC
Subjects
Animals
Bone Regeneration - physiology
Cells, Cultured
Dental Pulp - cytology
Dentistry
Disease Models, Animal
Feasibility Studies
Female
Green Fluorescent Proteins
Guided Tissue Regeneration - methods
Mandibular Diseases - surgery
Microscopy, Fluorescence
Osteogenesis - physiology
Reconstructive Surgical Procedures - methods
Research Reports
Stem Cell Transplantation
Stem Cells - physiology
Swine
Swine, Miniature
Tissue Engineering
Tissue Scaffolds
Tomography, X-Ray Computed
Tooth, Deciduous - cytology
Transplantation, Autologous
tissue engineering
bone
deciduous tooth
stem cell
miniature pig
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Summary:Stem cells from human exfoliated deciduous teeth have been identified as a new post-natal stem cell population with multipotential differentiation capabilities, including regeneration of mineralized tissues in vivo. To examine the efficacy of utilizing these stem cells in regenerating orofacial bone defects, we isolated stem cells from miniature pig deciduous teeth and engrafted the critical-size bone defects generated in swine mandible models. Our results indicated that stem cells from miniature pig deciduous teeth, an autologous and easily accessible stem cell source, were able to engraft and regenerate bone to repair critical-size mandibular defects at 6 months post-surgical reconstruction. This pre-clinical study in a large-animal model, specifically swine, allows for testing of a stem cells/scaffold construct in the restoration of orofacial skeletal defects and provides rapid translation of stem-cell-based therapy in orofacial reconstruction in human clinical trials.
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ISSN:0022-0345
1544-0591
DOI:10.1177/0022034509333804