Immunomodulatory Properties of Mesenchymal Stem Cells: Cytokines and Factors

• Published in: American journal of reproductive immunology (1989) Vol. 67; no. 1; pp. 1 - 8
• Main Authors: Soleymaninejadian, Ehsan, Pramanik, Krishna, Samadian, Esmaeil
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2012
• Subjects: Adipose Tissue - cytology; Adipose Tissue - immunology; Bone Marrow Cells - cytology; Bone Marrow Cells - immunology; Cell Differentiation - immunology; Cell Proliferation; Cytokines; Dinoprostone - immunology; Dinoprostone - metabolism; factors; Fetal Blood - cytology; Fetal Blood - immunology; Graft vs Host Disease - immunology; Graft vs Host Disease - prevention & control; Heme Oxygenase-1 - immunology; Heme Oxygenase-1 - metabolism; Hepatocyte Growth Factor - immunology; Hepatocyte Growth Factor - metabolism; HLA-G Antigens - immunology; HLA-G Antigens - metabolism; Humans; Immunity, Innate; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology; Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism; Interleukin-10 - immunology; Interleukin-10 - metabolism; Mesenchymal Stem Cell Transplantation; mesenchymal stem cells; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - immunology; Mesenchymal Stromal Cells - metabolism; T-Lymphocytes - cytology; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Transforming Growth Factor beta - immunology; Transforming Growth Factor beta - metabolism
• ISSN: 1046-7408; 1600-0897
• DOI: 10.1111/j.1600-0897.2011.01069.x

Citation Soleymaninejadian E, Pramanik K, Samadian E. Immunomodulatory properties of mesenchymal stem cells: cytokines and factors. Am J Reprod Immunol 2012; 67: 1–8 Mesenchymal stem cells (MSCs) are defined as undifferentiated cells that are capable of self renewal and differentiation into several cell types such as chondrocyte, adipocyte, osteocyte, myocyte, hepatocyte, and neuron‐like cells. MSC can be isolated from bone marrow, umbilical cord blood, adipose tissue, placenta, periosteum, trabecular bone, synovium, skeletal muscle, and deciduous teeth. Immunomodulatory of MSCs is one of the important issues nowadays, because this aspect can be clinically applied for graft‐versus‐host and autoimmune diseases. In this review, we tried to discuss in detail about cytokines and factors such as members of the transforming growth factor superfamily (transforming growth factor‐β), hepatic growth factors (HGF), prostaglandin E2 (PGE2), IL‐10, indolamine 2,3‐dioxygenase (IDO), nitric oxide (NO), heme oxygenase‐1 (HO‐1), and human leukocyte antigen‐G (HLA‐G) that are involved in immunomodulatory of MSCs.