Atypical slow waves generated in gastric corpus provide dominant pacemaker activity in guinea pig stomach
When intracellular recordings were made from the circular layer of the intact muscular wall of the isolated guinea pig gastric corpus, an ongoing regular high frequency discharge of slow waves was detected even though this region lacked myenteric interstitial cells. When slow waves were recorded fro...
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Published in | The Journal of physiology Vol. 569; no. 2; pp. 459 - 465 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
9600 Garsington Road , Oxford , OX4 2DQ , UK
The Physiological Society
01.12.2005
Blackwell Science Ltd Blackwell Science Inc |
Subjects | |
Online Access | Get full text |
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Summary: | When intracellular recordings were made from the circular layer of the intact muscular wall of the isolated guinea pig gastric
corpus, an ongoing regular high frequency discharge of slow waves was detected even though this region lacked myenteric interstitial
cells. When slow waves were recorded from preparations consisting of both the antrum and the corpus, slow waves of identical
frequency, but with different shapes, were generated in the two regions. Corporal slow waves could be distinguished from antral
slow waves by their time courses and amplitudes. Corporal slow waves, like antral slow waves, were abolished by buffering
the internal concentration of calcium ions, [Ca 2+ ] i , to low levels, or by caffeine, 2-aminoethoxydiphenyl borate or the chloride channel blocker DIDS. Corporal preparations
demonstrated an ongoing discharge of unitary potentials, as has been found in all other tissues containing interstitial cells.
The experiments show that the corpus provides the dominant pacemaker activity which entrains activity in other regions of
the stomach and it is suggested that this activity is generated by corporal intramuscular interstitial cells. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3751 1469-7793 |
DOI: | 10.1113/jphysiol.2005.097907 |