Subtypes of mild cognitive impairment in parkinson's disease: Progression to dementia

• Published in: Movement disorders Vol. 21; no. 9; pp. 1343 - 1349
• Main Authors: Janvin, Carmen Cristea, Larsen, Jan Petter, Aarsland, Dag, Hugdahl, Kenneth
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2006; Wiley
• Subjects: Aged; Aged, 80 and over; Amnesia - diagnosis; Biological and medical sciences; Cognition Disorders - diagnosis; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; dementia; Dementia - diagnosis; Diagnostic and Statistical Manual of Mental Disorders; Disability Evaluation; Disease Progression; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Medical sciences; Mental Status Schedule; Middle Aged; mild cognitive impairment; Nervous system (semeiology, syndromes); Neurologic Examination; Neurology; Neuropsychological Tests; Norway; Parkinson Disease - diagnosis; Parkinson's disease; Norway; Nervous system diseases; Parkinson's disease; Central nervous system disease; Parkinson disease; Degenerative disease; mild cognitive impairment; Subtype; Cerebral disorder; Extrapyramidal syndrome; Dementia
• ISSN: 0885-3185; 1531-8257
• DOI: 10.1002/mds.20974

The aim of this study was to establish the rate of progression from mild cognitive impairment (MCI) to dementia in patients with Parkinson's disease (PD). PD patients without dementia were recruited in 1997 from an ongoing prospective epidemiological study. The assessment included neurological and psychiatric examinations, a clinical interview based on the Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition (DSM‐III‐R) criteria for dementia, and a battery of neuropsychological tests. PD was diagnosed according to established criteria, dementia was diagnosed according to the DSM‐III‐R criteria, and subtypes of MCI were classified according to modified Petersen's criteria. Seventy‐two nondemented PD patients were included. A total of 34 were cognitively intact, whereas 38 were diagnosed with MCI (amnestic, n = 6; single nonmemory domain, n = 17; multiple domains slightly impaired, n = 15). Fifty‐nine patients (82%) completed follow‐up examination 4 years later, and 18 (62%) of the patients with MCI and 6 (20%) of the cognitively intact PD patients were demented (P = 0.001). Single domain nonmemory MCI and multiple domains slightly impaired MCI were associated with later development of dementia (P = 0.003; P = 0.04), whereas amnestic MCI subtype was not (P = 0.76). We conclude that patients with PD and MCI had a higher risk of developing dementia than cognitively intact PD patients, suggesting that MCI in PD is an early manifestation of dementia. However, these findings should be interpreted with caution due to the relatively small number of subjects included in this study. © 2006 Movement Disorder Society