Fungal metabolites. I. Isolation and biological activities of hypelcins A and B (growth inhibitors against Lentinus edodes) from Hypocrea peltata

Two new peptide antibiotics, hypelcins A and B, were isolated from Hypocrea peltata, which is antagonistic to Lentinus edodes. Hypelcins A and B are linear peptides which include nine or ten residues of the abnormal amino acid α-aminoisobutyric acid (Aib) and an amino alcohol, L-leucinol. Hypelcin A...

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Bibliographic Details
Published inChem. Pharm. Bull Vol. 32; no. 5; pp. 1822 - 1828
Main Authors Fuijta, T, Tasaishi, Y, Moritoki, H, Ogawa, T, Tokimoto, K
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1984
公益社団法人日本薬学会
Japan Science and Technology Agency
Subjects
alpha -aminoisobutyric acid
hypelcin
hypelcin A
hypelcin B
Hypocrea peltata
ileal contraction
Lentinus edodes
leucinol
peptide antibiotic
peptide antibiotics
plant biochemistry
plant physiology
α-aminoisobutyric acid
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Summary:Two new peptide antibiotics, hypelcins A and B, were isolated from Hypocrea peltata, which is antagonistic to Lentinus edodes. Hypelcins A and B are linear peptides which include nine or ten residues of the abnormal amino acid α-aminoisobutyric acid (Aib) and an amino alcohol, L-leucinol. Hypelcin A was confirmed to be an amide of hypelcin B by chemical conversion. Hypelcin A showed antifungal and antibacterial activities, and contractile action on guinea pig ileum.
Bibliography:ObjectType-Article-1
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ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.32.1822