Age-related changes of lateral ventricular width and periventricular white matter in the human brain： a diffusion tensor imaging study

• Published in: Neural regeneration research Vol. 9; no. 9; pp. 986 - 989
• Main Authors: Kwon, Yong Hyun, Jang, Sung Ho, Yeo, Sang Seok
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.05.2014; Medknow Publications & Media Pvt. Ltd; Department of Physical Therapy, Yeungnam University College, Namgu, Daegu, Republic of Korea%Department of Physical Medicine and Rehabilitation, College of Medi-cine, Yeungnam University, Namgu, Daegu, Republic of Korea%Department of Physical Therapy, College of Health Sciences, Dankook University, Dongnam-gu, Cheonan-si, Chungnam, Republic of Korea; Medknow Publications & Media Pvt Ltd
• Subjects: Age; Aging; Analysis; Anisotropy; Cognitive ability; Diagnostic imaging; Imaging in Neural Regeneration; Methods; 人脑; 侧脑室; 宽度; 年龄相关; 成像; 扩散张量; 生物标记物; 阿尔茨海默氏病; United States; United States > US
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.133152

Introduction Aging is the accumulation of multidimensional deterioration of process- ing of biological, psychological, and social changes with expansion over time （Bowen and Atwood, 2004; Grady, 2012）. Aging-related changes are typically accompanied by decline in cognitive function, urinary control, sensory-motor function, and gait ability （Bradley et al., 1991; Bowen and Atwood, 2004; Hedden and Gabrieli, 2004; Grady, 2012; Moran et al., 2012）. In addition, a number of studies have suggested changes in brain structure with normal aging, such as decrease in cortical thickness or increase in ventricular width （Blatter et al., 1995; Tang et al., 1997; Uylings and de Brabander, 2002; Preul et al., 2006; Apostolova et al., 2012）. In particular, ventricular enlargement has been suggested as a structural biomarker for normal aging and progression of some illnesses, such as Alzheimer＇s disease （Blatter et al., 1995; Tang et al.,