Inhibition of Human Immunodeficiency Virus Type 1 Replication by RNA Interference Directed against Human Transcription Elongation Factor P-TEFb (CDK9/CyclinT1)

• Published in: Journal of Virology Vol. 78; no. 5; pp. 2517 - 2529
• Main Authors: CHIU, Ya-Lin, HONG CAO, JACQUE, Jean-Marc, STEVENSON, Mario, RANA, Tariq M
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.03.2004
• Subjects: Biological and medical sciences; Cdk9 protein; Cell Line; Cyclin T; cyclin T1; Cyclin-Dependent Kinase 9 - genetics; Cyclin-Dependent Kinase 9 - metabolism; Cyclins - genetics; Cyclins - metabolism; Down-Regulation; Enzyme Stability; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Viral; Gene Products, tat - genetics; Gene Products, tat - metabolism; Genes, Lethal; HeLa Cells; HIV-1 - genetics; HIV-1 - physiology; Human immunodeficiency virus 1; Human viral diseases; Humans; Infectious diseases; Medical sciences; Microbiology; Miscellaneous; P-TEFb protein; Positive Transcriptional Elongation Factor B - chemistry; Positive Transcriptional Elongation Factor B - genetics; Positive Transcriptional Elongation Factor B - metabolism; Protein Subunits - genetics; Protein Subunits - metabolism; RNA Interference; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; tat Gene Products, Human Immunodeficiency Virus; Transcriptional Activation; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virology; Virus Replication; Human; Immunopathology; RNA interference; Microbiology; HIV-1 virus; Retroviridae; Elongation factor; AIDS; Immune deficiency; Lentivirus; Virology; Infection; Virus; Viral disease; Replication; Human immunodeficiency virus; Transcription factor
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.78.5.2517-2529.2004

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