Porcine noroviruses related to human noroviruses

• Published in: Emerging infectious diseases Vol. 11; no. 12; pp. 1874 - 1881
• Main Authors: Wang, Qiu-Hong, Han, Myung Guk, Cheetham, Sonia, Souza, Menira, Funk, Julie A, Saif, Linda J
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.12.2005; Centers for Disease Control and Prevention
• Subjects: Animals; calicivirus; Capsid Proteins - genetics; Diagnosis; Feces - virology; Genetic Variation; Genotype; Humans; Identification and classification; norovirus; Norovirus - classification; Norovirus - genetics; Norovirus - ultrastructure; Phylogeny; porcine; recombinant; Recombination, Genetic - genetics; RNA viruses; Swine - virology; United States
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid1112.050485

Detection of genogroup II (GII) norovirus (NoV) RNA from adult pigs in Japan and Europe and GII NoV antibodies in US swine raises public health concerns about zoonotic transmission of porcine NoVs to humans, although no NoVs have been detected in US swine. To detect porcine NoVs and to investigate their genetic diversity and relatedness to human NoVs, 275 fecal samples from normal US adult swine were screened by reverse transcription-polymerase chain reaction with calicivirus universal primers. Six samples were positive for NoV. Based on sequence analysis of 3 kb on the 3' end of 5 porcine NoVs, 3 genotypes in GII and a potential recombinant were identified. One genotype of porcine NoVs was genetically and antigenically related to human NoVs and replicated in gnotobiotic pigs. These results raise concerns of whether subclinically infected adult swine may be reservoirs of new human NoVs or if porcine/human GII recombinants could emerge.