Stimulation of Immunoreactive Somatostatin Release from Hypothalamic Synaptosomes by High (K+) and Dopamine
Effects of high (K+) and dopamine on the release of immunoreactive somatostatin from isolated hypothalamic synaptosomes were studied in rats. High (K+)(60 mM) and dopamine (10-6 M) in the incubation media stimulated the release of immunoreactive somatostatin and the former effect was completely abol...
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Published in | Endocrinologia Japonica Vol. 24; no. 6; pp. 601 - 604 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Japan
The Japan Endocrine Society
01.01.1977
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Abstract | Effects of high (K+) and dopamine on the release of immunoreactive somatostatin from isolated hypothalamic synaptosomes were studied in rats. High (K+)(60 mM) and dopamine (10-6 M) in the incubation media stimulated the release of immunoreactive somatostatin and the former effect was completely abolished by the removal of Ca++ from the media. These suggest that hypothalamic somatostatinergic synaptosomes preserved at least one of the important basic properties of secretory cells. Although it is of interest to note that dopamine stimulated the release of somatostatin. Its physiological significance awaits further studies. |
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AbstractList | Effects of high (K+) and dopamine on the release of immunoreactive somatostatin from isolated hypothalamic synaptosomes were studied in rats. High (K+) (60 mM) and dopamine (10(-6) M) in the incubation media stimulated the release of immunoreactive somatostatin and the former effect was completely abolished by the removal of Ca++ from the media. These suggest that hypothalamic somatostatinergic synaptosomes preserved at least one of the important basic properties of secretory cells. Although it is of interest to note that dopamine stimulated the release of somatostatin. Its physiological significance awaits further studies. |
Author | MIYAZAWA, YUJI WAKABAYASHI, ICHIJI SHIZUME, KAZUO DEMURA, HIROSHI KANDA, MEGUMI MIKI, NOBUHIRO DEMURA, REIKO |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/606549$$D View this record in MEDLINE/PubMed |
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Snippet | Effects of high (K+) and dopamine on the release of immunoreactive somatostatin from isolated hypothalamic synaptosomes were studied in rats. High (K+)(60 mM)... Effects of high (K+) and dopamine on the release of immunoreactive somatostatin from isolated hypothalamic synaptosomes were studied in rats. High (K+) (60 mM)... |
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SubjectTerms | Animals Antigen-Antibody Reactions Calcium - pharmacology Dopamine - pharmacology Hypothalamus - metabolism In Vitro Techniques Male Potassium - pharmacology Rats Somatostatin - immunology Somatostatin - metabolism Synaptosomes - metabolism |
Title | Stimulation of Immunoreactive Somatostatin Release from Hypothalamic Synaptosomes by High (K+) and Dopamine |
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