Stimulation of Immunoreactive Somatostatin Release from Hypothalamic Synaptosomes by High (K+) and Dopamine

Effects of high (K+) and dopamine on the release of immunoreactive somatostatin from isolated hypothalamic synaptosomes were studied in rats. High (K+)(60 mM) and dopamine (10-6 M) in the incubation media stimulated the release of immunoreactive somatostatin and the former effect was completely abol...

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Published inEndocrinologia Japonica Vol. 24; no. 6; pp. 601 - 604
Main Authors WAKABAYASHI, ICHIJI, MIYAZAWA, YUJI, KANDA, MEGUMI, MIKI, NOBUHIRO, DEMURA, REIKO, DEMURA, HIROSHI, SHIZUME, KAZUO
Format Journal Article
LanguageEnglish
Published Japan The Japan Endocrine Society 01.01.1977
Subjects
Animals
Antigen-Antibody Reactions
Calcium - pharmacology
Dopamine - pharmacology
Hypothalamus - metabolism
In Vitro Techniques
Male
Potassium - pharmacology
Rats
Somatostatin - immunology
Somatostatin - metabolism
Synaptosomes - metabolism
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Summary:Effects of high (K+) and dopamine on the release of immunoreactive somatostatin from isolated hypothalamic synaptosomes were studied in rats. High (K+)(60 mM) and dopamine (10-6 M) in the incubation media stimulated the release of immunoreactive somatostatin and the former effect was completely abolished by the removal of Ca++ from the media. These suggest that hypothalamic somatostatinergic synaptosomes preserved at least one of the important basic properties of secretory cells. Although it is of interest to note that dopamine stimulated the release of somatostatin. Its physiological significance awaits further studies.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0013-7219
2185-6370
DOI:10.1507/endocrj1954.24.601