Effects of a Chicken Collagen Hydrolysate on the Circulation System in Subjects with Mild Hypertension or High-Normal Blood Pressure

• Published in: Bioscience, biotechnology, and biochemistry Vol. 77; no. 4; pp. 691 - 696
• Main Authors: KOUGUCHI, Tomomi, OHMORI, Takashi, SHIMIZU, Muneshige, TAKAHATA, Yoshihisa, MAEYAMA, Yoshiaki, SUZUKI, Takuya, MORIMATSU, Fumiki, TANABE, Soichi
• Format: Journal Article
• Language: English
• Published: England Japan Society for Bioscience, Biotechnology, and Agrochemistry 2013; Oxford University Press
• Subjects: angiotensin converting enzyme (ACE)-inhibitory activity; Animals; arterial stiffness; biotechnology; Blood Chemical Analysis; Blood Circulation; Blood Pressure; blood serum; Body Mass Index; Body Weight; brachial-ankle pulse wave velocity (baPWV); Cardiovascular System - physiopathology; Chickens; circulation system; collagen; Collagen - metabolism; collagen peptides; diastolic blood pressure; Female; food groups; Heart Rate; Humans; hydrolysates; Hydrolysis; hypertension; Hypertension - blood; Hypertension - diet therapy; Hypertension - physiopathology; Hypertension - urine; Male; Middle Aged; nitrogen oxides; placebos; Pulse Wave Analysis; systolic blood pressure; test meals; Urinalysis
• ISSN: 0916-8451; 1347-6947; 1347-6947
• DOI: 10.1271/bbb.120718

We investigated the effects of a chicken collagen hydrolysate (CCH) on the circulation system in humans. A total of 58 subjects with either mild hypertension (systolic blood pressure (SBP) of 140-159 mmHg or diastolic blood pressure (DBP) 90-99 mmHg) or high-normal blood pressure (SBP 130-139 mmHg or DBP 85-89 mmHg) were assigned to two groups, one involving a placebo and the other, the test food (including CCH of 2.9 g/d). The parameters related to each subject's circulation system were monitored over the study period of 18 weeks. The Δbrachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness and marker of vascular damage, was significantly lower in the test food group than in the placebo group during the treatment period. The blood pressure in the test food group was also significantly lower than that in the placebo group, while the serum nitrogen oxide was higher in the test food group after the treatment. These results suggest that CCH exerted modulatory effects on the human circulation system.