New sequence variants associated with bone mineral density

In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF...

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Published inNature genetics Vol. 41; no. 1; pp. 15 - 17
Main Authors Styrkarsdottir, Unnur, Stefansson, Kari, Halldorsson, Bjarni V, Gretarsdottir, Solveig, Gudbjartsson, Daniel F, Walters, G Bragi, Ingvarsson, Thorvaldur, Jonsdottir, Thorbjorg, Saemundsdottir, Jona, Snorradóttir, Steinunn, Center, Jacqueline R, Nguyen, Tuan V, Alexandersen, Peter, Gulcher, Jeffrey R, Eisman, John A, Christiansen, Claus, Sigurdsson, Gunnar, Kong, Augustine, Thorsteinsdottir, Unnur
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.01.2009
Nature Publishing Group
Subjects
Agriculture
Animal Genetics and Genomics
Base Sequence
Binding sites
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Bone density
Bone Density - genetics
Bone mineral density
Bones
brief-communication
Cancer Research
Chromosomes, Human, Pair 17 - genetics
Density
Female
Fractures
Fractures, Bone - complications
Fractures, Bone - genetics
Fundamental and applied biological sciences. Psychology
Gene Function
Genes
Genetic aspects
Genetics of eukaryotes. Biological and molecular evolution
Genome-Wide Association Study
Health aspects
Human Genetics
Humans
Kinases
Male
Physiological aspects
Polymorphism, Single Nucleotide - genetics
Proteins
Risk factors
Sample size
Single nucleotide polymorphisms
Wounds and Injuries - complications
Wounds and Injuries - genetics
Iceland
Osteoarticular system
Variant
Bone
Density
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Summary:In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1061-4036
1546-1718
DOI:10.1038/ng.284