Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents

Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolam...

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Bibliographic Details
Published inBiomaterials Vol. 170; pp. 26 - 36
Main Authors Upponi, Jaydev R., Jerajani, Kaushal, Nagesha, Dattatri K., Kulkarni, Praveen, Sridhar, Srinivas, Ferris, Craig, Torchilin, Vladimir P.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.07.2018
Subjects
Animals
Apoptosis - drug effects
Cancer therapy
Cell Line, Tumor
Contrast Media - chemistry
Diagnostics
Drug delivery
Drug Delivery Systems
Female
Magnetic Resonance Imaging
Magnetite Nanoparticles - chemistry
Magnetite Nanoparticles - ultrastructure
Male
Mice, Inbred BALB C
Mice, Inbred C57BL
Micelles
Nanoparticles
Neoplasms - diagnostic imaging
Neoplasms - drug therapy
Neoplasms - pathology
Paclitaxel - administration & dosage
Paclitaxel - pharmacology
Paclitaxel - therapeutic use
Polymers - chemistry
Solubility
Theranostic Nanomedicine - methods
Theranostics
Water - chemistry
Nanoparticles
Drug delivery
Diagnostics
Theranostics
Micelles
Cancer therapy
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Summary:Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolamine-based micelles loaded with both, poorly soluble chemotherapeutic agent paclitaxel and hydrophobic superparamagnetic iron oxide nanoparticles (SPION), a Magnetic Resonance Imaging contrast agent. The co-loaded paclitaxel and SPION did not affect each other's functional properties in vitro. In vivo, the resulting paclitaxel-SPION-co-loaded PEG-PE micelles retained their Magnetic Resonance contrast properties and apoptotic activity in breast and melanoma tumor mouse models. Such theranostic systems are likely to play a significant role in the combined diagnosis and therapy that leads to a more personalized and effective form of treatment.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2018.03.054