Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells

MicroRNAs (miRNAs) are 20-nt-long to 24-nt-long noncoding RNAs acting as post-transcriptional regulators of gene expression in animals and plants. In mammals, more than 50% of mRNAs are predicted to be the subject of miRNA-mediated control but mechanistic aspects of the regulation are not fully unde...

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Published inCurrent opinion in cell biology Vol. 21; no. 3; pp. 452 - 460
Main Authors Chekulaeva, Marina, Filipowicz, Witold
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2009
Subjects
Animals
Cells - metabolism
Gene Expression Regulation
Internal Medicine
MicroRNAs - physiology
Models, Biological
RNA Processing, Post-Transcriptional
RNA, Messenger - metabolism
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Summary:MicroRNAs (miRNAs) are 20-nt-long to 24-nt-long noncoding RNAs acting as post-transcriptional regulators of gene expression in animals and plants. In mammals, more than 50% of mRNAs are predicted to be the subject of miRNA-mediated control but mechanistic aspects of the regulation are not fully understood and different studies have produced often-contradictory results. miRNAs can affect both the translation and stability of mRNAs. In this report, we review current progress in understanding how miRNAs execute these effects in animals and we discuss some of the controversies regarding different modes of miRNA function.
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ISSN:0955-0674
1879-0410
1879-0410
DOI:10.1016/j.ceb.2009.04.009