Diagnosis and management of clinical chorioamnionitis

Chorioamnionitis is a common complication of pregnancy associated with significant maternal, perinatal, and long-term adverse outcomes. Adverse maternal outcomes include postpartum infections and sepsis whereas adverse infant outcomes include stillbirth, premature birth, neonatal sepsis, chronic lun...

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Bibliographic Details
Published inClinics in perinatology Vol. 37; no. 2; p. 339
Main Authors Tita, Alan T N, Andrews, William W
Format Journal Article
LanguageEnglish
Published United States 01.06.2010
Subjects
Chorioamnionitis - diagnosis
Chorioamnionitis - epidemiology
Chorioamnionitis - microbiology
Chorioamnionitis - therapy
Diagnosis, Differential
Female
Humans
Infant, Newborn
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - epidemiology
Pregnancy Complications, Infectious - microbiology
Pregnancy Complications, Infectious - therapy
Pregnancy Outcome
Risk Factors
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Summary:Chorioamnionitis is a common complication of pregnancy associated with significant maternal, perinatal, and long-term adverse outcomes. Adverse maternal outcomes include postpartum infections and sepsis whereas adverse infant outcomes include stillbirth, premature birth, neonatal sepsis, chronic lung disease, and brain injury leading to cerebral palsy and other neurodevelopmental disabilities. Research in the past 2 decades has expanded understanding of the mechanistic links between intra-amniotic infection and preterm delivery as well as morbidities of preterm and term infants. Recent and ongoing clinical research into better methods for diagnosing, treating, and preventing chorioamnionitis is likely to have a substantial impact on short and long-term outcomes in the neonate.
ISSN:1557-9840
DOI:10.1016/j.clp.2010.02.003