NAMPT inhibitor protects ischemic neuronal injury in rat brain via anti-neuroinflammation

• Published in: Neuroscience Vol. 356; pp. 193 - 206
• Main Authors: Chen, Chen-Xiang, Huang, Jing, Tu, Ga-Qi, Lu, Jia-Tong, Xie, Xian, Zhao, Bing, Wu, Ming, Shi, Qiao-Juan, Fang, San-Hua, Wei, Er-Qing, Zhang, Wei-Ping, Lu, Yun-Bi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 25.07.2017
• Subjects: Animals; Brain - drug effects; Brain - metabolism; cerebral ischemia; Disease Models, Animal; FK866; Ischemia - drug therapy; Ischemia - metabolism; Macrophages - drug effects; Macrophages - metabolism; Male; Microglia - drug effects; microglia/macrophage; Neurology; Neurons - drug effects; Neurons - metabolism; Neuroprotective Agents - pharmacology; NF-kappa B - metabolism; nicotinamide phosphoribosyltransferase (NAMPT); Nicotinamide Phosphoribosyltransferase - drug effects; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha - metabolism; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; middle cerebral artery occlusion and reperfusion; phosphate-buffered saline; pre-B cell colony enhancing factor; MTT; nicotinamide adenine dinucleotide; LDH; OGD/R; NAMPT; internal carotid artery; PBS; Nicotinamide phosphoribosyltransferase (NAMPT); ECA; EI; ICA; lactate dehydrogenase; MCA; NMN; middle cerebral artery; FK866; GFAP; NAD; oxygen-glucose deprivation and recovery; Cerebral ischemia; MCAO/R; NeuN; PBEF; Nicotinamide phosphoribosyltransferase; neuronal nuclear; enzyme-linked immunosorbent assay; enzyme I, a signaling protein from the phosphotransferase system of bacteria; Microglia/macrophage; nicotinamide mononucleotide; glial fibrillary acidic protein; external carotid artery; ELISA; microglia/macrophage; nicotinamide phosphoribosyltransferase (NAMPT); cerebral ischemia
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2017.05.022

Graphical abstract