Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution

Lethally irradiated rats treated with cyclosporin A (CsA) for 20-40 d develop classic graft-versus-host disease (GVHD) when reconstituted with syngeneic or autologous bone marrow, upon discontinuation of CsA, whereas normal rats do not. Syngeneic GVHD may be transferred to irradiated but not normal...

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Published inThe Journal of experimental medicine Vol. 158; no. 1; pp. 1 - 8
Main Authors GLAZIER, A, TUTSCHKA, P. J, FARMER, E. R, SANTOS, G. W
Format Journal Article
LanguageEnglish
Published New York, NY Rockefeller University Press 01.07.1983
The Rockefeller University Press
Subjects
Animals
Biological and medical sciences
Bone Marrow - radiation effects
Bone Marrow Transplantation
Cyclosporins - administration & dosage
Cyclosporins - therapeutic use
Female
Graft vs Host Disease - pathology
Graft vs Host Disease - prevention & control
Immunomodulators
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Inbred Lew
Spleen - cytology
Spleen - transplantation
Transplantation, Homologous
Transplantation, Isogeneic
Autologous host
Vertebrata
Mammalia
Rat
Rodentia
Bone marrow
Graft versus host reaction
Immunosuppressive agent
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Summary:Lethally irradiated rats treated with cyclosporin A (CsA) for 20-40 d develop classic graft-versus-host disease (GVHD) when reconstituted with syngeneic or autologous bone marrow, upon discontinuation of CsA, whereas normal rats do not. Syngeneic GVHD may be transferred to irradiated but not normal syngeneic recipients. Normal spleen cells fail to prevent the development or adoptive transfer of syngeneic GVHD.
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ISSN:0022-1007
1540-9538
DOI:10.1084/jem.158.1.1