Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes

• Published in: Bioengineering (Basel) Vol. 10; no. 8; p. 898
• Main Authors: Boëx, Colette, Awadhi, Abdullah Al, Tyrand, Rémi, Corniola, Marco V, Kibleur, Astrid, Fleury, Vanessa, Burkhard, Pierre R, Momjian, Shahan
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 28.07.2023; MDPI
• Subjects: Bioengineering; Deep brain stimulation; Electrical stimuli; Electrodes; Image reconstruction; lead-DBS; local field potentials; Localization; Movement disorders; Neurodegenerative diseases; Oscillations; Parkinson's disease; Power; Sensorimotor system; Single wires; Solitary tract nucleus; Stimulation; Subthalamic nucleus; Surgery; United States; United States > US; Germany
• ISSN: 2306-5354; 2306-5354
• DOI: 10.3390/bioengineering10080898

In deep brain stimulation (DBS) studies in patients with Parkinson’s disease, the Lead-DBS toolbox allows the reconstruction of the location of β-oscillations in the subthalamic nucleus (STN) using Vercise Cartesia directional electrodes (Boston Scientific). The objective was to compare these probabilistic locations with those of intraoperative monopolar β-oscillations computed from local field potentials (0.5–3 kHz) recorded by using shielded single wires and an extracranial shielded reference electrode. For each electrode contact, power spectral densities of the β-band (13–31 Hz) were compared with those of all eight electrode contacts on the directional electrodes. The DBS Intrinsic Template AtLas (DISTAL), electrophysiological, and DBS target atlases of the Lead-DBS toolbox were applied to the reconstructed electrodes from preoperative MRI and postoperative CT. Thirty-six electrodes (20 patients: 7 females, 13 males; both STN electrodes for 16 of 20 patients; one single STN electrode for 4 of 20 patients) were analyzed. Stimulation sites both dorsal and/or lateral to the sensorimotor STN were the most efficient. In 33 out of 36 electrodes, at least one contact was measured with stronger β-oscillations, including 23 electrodes running through or touching the ventral subpart of the β-oscillations’ probabilistic volume, while 10 did not touch it but were adjacent to this volume; in 3 out of 36 electrodes, no contact was found with β-oscillations and all 3 were distant from this volume. Monopolar local field potentials confirmed the ventral subpart of the probabilistic β-oscillations.