Synthetic biology approaches to actinomycete strain improvement

ABSTRACT Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advance...

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Published inFEMS microbiology letters Vol. 368; no. 10; pp. 1 - 9
Main Authors Breitling, Rainer, Avbelj, Martina, Bilyk, Oksana, Carratore, Francesco Del, Filisetti, Alessandro, Hanko, Erik K R, Iorio, Marianna, Redondo, Rosario Pérez, Reyes, Fernando, Rudden, Michelle, Severi, Emmanuele, Slemc, Lucija, Schmidt, Kamila, Whittall, Dominic R, Donadio, Stefano, García, Antonio Rodríguez, Genilloud, Olga, Kosec, Gregor, De Lucrezia, Davide, Petković, Hrvoje, Thomas, Gavin, Takano, Eriko
Format Journal Article
LanguageEnglish
Published England Oxford University Press 11.06.2021
Subjects
Actinobacteria - genetics
Actinobacteria - metabolism
Actinomycetes
Biological research
Biology
Biology, Experimental
Biosynthesis
Biotechnology
Chemical properties
Genetic aspects
Genetic engineering
Industrial Microbiology - methods
Industrial Microbiology - trends
Metabolic Engineering
Microbiology
Mini Review
Minireview
Synthetic biology
Synthetic Biology - methods
Synthetic Biology - trends
United Kingdom
actinobacteria
actinomycete
synthetic biology
biotechnology
biosynthesis
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Summary:ABSTRACT Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains. Recent advances in synthetic biology driven engineering of the actinomycetes for the production of valuable drug compounds.
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Present address: Biosciences Institute, Microbes in Health and Disease Theme, Newcastle University
ISSN:1574-6968
0378-1097
1574-6968
DOI:10.1093/femsle/fnab060