Rapamycin promotes Schwann cell migration and nerve growth factor secretion

• Published in: Neural regeneration research Vol. 9; no. 6; pp. 602 - 609
• Main Authors: Liu, Fang, Zhang, Haiwei, Zhang, Kaiming, Wang, Xinyu, Li, Shipu, Yin, Yixia
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 15.03.2014; Medknow Publications & Media Pvt. Ltd; Department of 0rthopedics, Second Hospital of Yueyang, Yueyang, Hunan Province, China%State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan, Hunan Province, China; Medknow Publications & Media Pvt Ltd
• Subjects: Autophagy; Cell adhesion & migration; Cell cycle; Cell growth; Clinical trials; Complications and side effects; Dosage and administration; Drug dosages; FK506; Genetic aspects; Growth factors; Hypertension; Kinases; Ligands; Nerve growth factor; Nervous system; Phosphorylation; Physiological aspects; Proteins; Rapamycin; Regeneration; Research and Report; Schwann cells; 分泌; 周围神经再生; 生长相关蛋白; 神经生长因子; 细胞迁移; 雪旺氏细胞; 雷帕霉素; China; neural regeneration; Schwann cell; nerve growth factor; cell migration; growth-associated protein 43; nerve regeneration; peripheral nerve injury; FK506; NSFC grant; rapamycin; cell mi-gration

Rapamycin, similar to FKS06, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapamycin and FK506 in promoting peripheral nerve regeneration were similar. This study compared the effects of different concentrations of raparnycin and FK506 on Sc hwann cells and in...