An overview on antiepileptic drugs

Epilepsy is the most common chronic neurological disorder of the brain. For several decades different kinds of medications have been used to treat epilepsy. Even though many surgical advances has been made and implemented, medications remain the basis of treatment. The search for noble antiepileptic...

Full description

Saved in:
Bibliographic Details
Published inDrug Discoveries & Therapeutics Vol. 6; no. 4; pp. 178 - 193
Main Authors Das, Nirupam, Dhanawat, Meenakshi, Shrivastava, Sushant K.
Format Journal Article
LanguageEnglish
Published Japan International Research and Cooperation Association for Bio & Socio-Sciences Advancement 01.08.2012
Subjects
anticonvulsants
Anticonvulsants - administration & dosage
Anticonvulsants - adverse effects
Anticonvulsants - chemistry
Anticonvulsants - therapeutic use
Clinical Trials as Topic
combination therapy
Drug Discovery
Drug Resistance
Drug Therapy, Combination
Epilepsy
Epilepsy - drug therapy
Epilepsy - etiology
Humans
Molecular Structure
resistance
Online AccessGet full text

Cover

More Information
Summary:Epilepsy is the most common chronic neurological disorder of the brain. For several decades different kinds of medications have been used to treat epilepsy. Even though many surgical advances has been made and implemented, medications remain the basis of treatment. The search for noble antiepileptic drugs (AEDs) with more selective activity and lower toxicity continues to be an area of intensive investigation in medicinal chemistry. Additionally, drug resistance is an important clinical problem in epilepsy and is associated with an increased risk of morbidity and mortality. This review intends to present a comprehensive overview on AED in particular along with discussion on some aspects of associated drug resistance and combination therapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1881-7831
1881-784X
DOI:10.5582/ddt.2012.v6.4.178