The recolonization hypothesis in a full-mouth or multiple-session treatment protocol: a blinded, randomized clinical trial

• Published in: Journal of clinical periodontology Vol. 37; no. 6; pp. 518 - 525
• Main Authors: Zijnge, Vincent, Meijer, Henriette F., Lie, Mady-Ann, Tromp, Jan A. H., Degener, John E., Harmsen, Hermie J. M., Abbas, Frank
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2010; Blackwell
• Subjects: Adult; Aged; Aggregatibacter actinomycetemcomitans - growth & development; bacteria; Bacteria - classification; Bacteria - growth & development; Bacteroides - growth & development; Biological and medical sciences; Chronic Periodontitis - microbiology; Chronic Periodontitis - therapy; Clinical Protocols; Colony Count, Microbial; Dental Plaque Index; Dental Scaling - methods; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; Follow-Up Studies; full-mouth-SRP; Furcation Defects - microbiology; Furcation Defects - therapy; Fusobacterium nucleatum - growth & development; Gingival Hemorrhage - microbiology; Gingival Hemorrhage - therapy; Humans; Male; Medical sciences; Middle Aged; multiple session SRP; Non tumoral diseases; Otorhinolaryngology. Stomatology; Periodontal Index; Periodontal Pocket - microbiology; Periodontal Pocket - therapy; periodontitis; polymerase chain reaction; Porphyromonas gingivalis - growth & development; recolonization; Root Planing - methods; Subgingival Curettage - methods; Treatment Outcome; Treponema denticola - growth & development; Multiple; Stomatology; Dentistry; Polymerase chain reaction; Oral cavity; Periodontal disease; multiple session SRP; Treatment; Periodontitis; Bacteria; Clinical trial; full-mouth-SRP; Molecular biology; recolonization
• ISSN: 0303-6979; 1600-051X; 1600-051X
• DOI: 10.1111/j.1600-051X.2010.01562.x

Zijnge V, Meijer HF, Lie MA, Tromp JAH, Degener JE, Harmsen HJM, Abbas F: The recolonization hypothesis in a full‐mouth or multiple‐session treatment protocol: a blinded, randomized clinical trial. J Clin Peridontol 2010; 37: 518–525. doi: 10.1111/j.1600‐051X.2010.01562.x. Aim: To test recolonization of periodontal lesions after full‐mouth scaling and root planing (FM‐SRP) or multiple session‐SRP (MS‐SRP) in a randomized clinical trial and whether FM‐SRP and MS‐SRP result in different clinical outcomes. Materials and Methods: Thirty‐nine subjects were randomly assigned to FM‐SRP or MS‐SRP groups. At baseline and after 3 months, probing pocket depth (PPD), plaque index (PlI) and bleeding on probing (BoP) were recorded. At baseline, immediately after treatment, after 1, 2, 7, 14 and 90 days, paper point samples from a single site from the maxillary right quadrant were collected for microbiological analysis of five putative pathogens by polymerase chain reaction. Results: FM‐SRP and MS‐SRP resulted in significant reductions in PPD, BoP and PlI and the overall detection frequencies of the five species after 3 months without significant differences between treatments. Compared with MS‐SRP, FM‐SRP resulted in less recolonization of the five species, significantly for Treponema denticola, in the tested sites. Conclusion: FM‐SRP and MS‐SRP result in overall clinically and microbiologically comparable outcomes where recolonization of periodontal lesions may be better prevented by FM‐SRP.