The "Aryne" Route to Biaryls Featuring Uncommon Substituent Patterns

1,2‐Didehydroarenes (“arynes”) mediate as extremely reactive, short‐lived intermediates in selective aryl–aryl coupling processes to form biaryls with unprecedented substituent patterns (see scheme, X=H, F, Cl). Possible applications include the synthesis of novel ligands for asymmetric catalysis....

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Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 41; no. 22; pp. 4272 - 4274
Main Authors Leroux, Frédéric, Schlosser, Manfred
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 15.11.2002
WILEY‐VCH Verlag
Wiley
Subjects
aryl-aryl coupling
arynes
atropisomerism
biaryls
Chemistry
Chemistry, Multidisciplinary
lithium reagents
Physical Sciences
Science & Technology
arynes
aryl-aryl coupling
biaryls
LIGANDS
lithium reagents
atropisomerism
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Summary:1,2‐Didehydroarenes (“arynes”) mediate as extremely reactive, short‐lived intermediates in selective aryl–aryl coupling processes to form biaryls with unprecedented substituent patterns (see scheme, X=H, F, Cl). Possible applications include the synthesis of novel ligands for asymmetric catalysis.
Bibliography:ArticleID:ANIE4272
This work was supported by the Swiss National Science Foundation, Bern (grant 20-63′584-00).
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istex:10ADF704E0A3EF31B057BB6AFE6FD6A22282BF4E
This work was supported by the Swiss National Science Foundation, Bern (grant 20‐63′584‐00).
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ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20021115)41:22<4272::AID-ANIE4272>3.0.CO;2-B