SRY-Negative XX Sex Reversal in a French Bulldog

• Published in: Reproduction in domestic animals Vol. 46; no. 1; pp. 185 - 188
• Main Authors: Campos, M, Moreno-Manzano, V, García-Roselló, M, García-Roselló, E
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2011; Blackwell
• Subjects: Animals; Biological and medical sciences; Disorders of Sex Development - pathology; Disorders of Sex Development - surgery; Disorders of Sex Development - veterinary; Dog Diseases - genetics; Dog Diseases - pathology; Dog Diseases - surgery; Dogs; Female; Fundamental and applied biological sciences. Psychology; Male; Mammalian reproduction. General aspects; Sex-Determining Region Y Protein - analysis; Testis - pathology; Vertebrates: reproduction; X Chromosome; France; Europe; Vertebrata; Sex reversal; Mammalia; Testis-determining factor
• ISSN: 0936-6768; 1439-0531
• DOI: 10.1111/j.1439-0531.2010.01612.x

Here, we describe a 3-month-old XX male French Bulldog. The diagnosis was based on the clinical signs, gonadal histology and cytogenetic analysis. Additionally, the dog was confirmed to be Sry negative by semi-quantitative reverse transcription polymerase chain reaction (sqRT-PCR). Canine Sry-negative XX sex reversal is a disorder of gonadal development where individuals who have a female karyotype develop testes or ovotestes. To our knowledge, this case is the first XX male sex reversion described in a French Bulldog.