Survival rates and prognostic factors for infiltrating salivary duct carcinoma: Analysis of 228 cases from the Surveillance, Epidemiology, and End Results database

• Published in: Head & neck Vol. 36; no. 5; pp. 694 - 701
• Main Authors: Jayaprakash, Vijayvel, Merzianu, Mihai, Warren, Graham W., Arshad, Hassan, Hicks Jr, Wesley L., Rigual, Nestor R., Sullivan, Maureen A., Seshadri, Mukund, Marshall, James R., Cohan, David M., Zhao, Yujie, Singh, Anurag K.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.05.2014; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Aged, 80 and over; Analysis of Variance; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - radiotherapy; Carcinoma, Squamous Cell - surgery; Combined Modality Therapy; Databases, Factual; Disease-Free Survival; Female; Humans; Lymph Node Excision; Lymph Nodes - pathology; Male; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness - pathology; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - therapy; Neoplasm Staging; Prognosis; prognostic factors; Proportional Hazards Models; radiation; Radiotherapy, Adjuvant; Risk Assessment; salivary duct carcinoma; Salivary Ducts - pathology; Salivary Gland Neoplasms - mortality; Salivary Gland Neoplasms - pathology; Salivary Gland Neoplasms - radiotherapy; Salivary Gland Neoplasms - surgery; SEER; SEER Program; Survival Rate; survival rates; Treatment Outcome; United States; United States; SEER; prognostic factors; radiation; salivary duct carcinoma; survival rates
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.23350

Background The survival rates and prognostic factors for salivary duct carcinoma (SDC) are not clear. Methods Survival estimates and prognostic factors were evaluated for 228 patients with SDC identified from the Surveillance, Epidemiology, and End Results (SEER) database. Results Median overall survival (OS) duration for patients with SDC was 79 months and 5‐year disease‐specific survival (DSS) rate was 64%. Among patients with SDC with lymph node involvement, larger primary tumor size (>3 cm) was associated with twice the risk of death (p < .03). Factors predictive of improved DSS were age (p = .01), tumor size (p = .006), tumor grade (p = .02), and lymph node involvement (p < .001). Adjuvant radiotherapy did not improve survival when compared to surgery alone for early‐stage (I–II) disease (p = .28). Conclusion Younger patients with SDC (<50 years) showed a better prognosis. Primary tumor size and lymph node involvement were independent and additive risk factors for poor prognosis. The role of adjuvant radiotherapy in the treatment of SDC needs to be explored further. © 2013 Wiley Periodicals, Inc. Head Neck 36: 694–701, 2014