The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer

• Published in: Metabolites Vol. 13; no. 6; p. 703
• Main Authors: Plaza-Diaz, Julio, Álvarez-Mercado, Ana Isabel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.05.2023; MDPI
• Subjects: Amino acids; Analysis; Bile acids; Breast cancer; Cancer; Cancer therapies; Care and treatment; Cell growth; Chemotherapy; Complications and side effects; Diagnosis; diet; Drug resistance; Epidermal growth factor; Estrogens; Fatty acids; Health aspects; Histopathology; host metabolism; Immunotherapy; Kinases; Lymphatic system; Metabolism; Metabolites; Metabolomics; Metagenomics; Metastasis; Microbiota; Microbiota (Symbiotic organisms); NMR; Nuclear magnetic resonance; Patient outcomes; Patients; Radiation therapy; Review; Risk factors; Scientific imaging; Surgery; Tumorigenesis; Tumors; Womens health; Spain; microbiota; breast cancer; host metabolism; diet; chemotherapy; metabolites
• ISSN: 2218-1989; 2218-1989
• DOI: 10.3390/metabo13060703

The most common cancer in women is breast cancer, which is also the second leading cause of death in this group. It is, however, important to note that some women will develop or will not develop breast cancer regardless of whether certain known risk factors are present. On the other hand, certain compounds are produced by bacteria in the gut, such as short-chain fatty acids, secondary bile acids, and other metabolites that may be linked to breast cancer development and mediate the chemotherapy response. Modeling the microbiota through dietary intervention and identifying metabolites directly associated with breast cancer and its complications may be useful to identify actionable targets and improve the effect of antiangiogenic therapies. Metabolomics is therefore a complementary approach to metagenomics for this purpose. As a result of the combination of both techniques, a better understanding of molecular biology and oncogenesis can be obtained. This article reviews recent literature about the influence of bacterial metabolites and chemotherapy metabolites in breast cancer patients, as well as the influence of diet.