Swept Source-Optical Coherence Tomography Angiography for Management of Secondary Choroidal Neovascularization in Punctate Inner Choroidopathy

The purpose was to demonstrate the diagnostic and therapeutic feasibility of swept source-optical coherence tomography angiography (SS-OCTA) by picturing neovascular changes secondary to a rare white dot syndrome following long-term intravitreal ranibizumab (IVR). A 28-year-old Caucasian myopic fema...

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Bibliographic Details
Published inCase reports in ophthalmology Vol. 12; no. 1; pp. 232 - 238
Main Authors Stattin, Martin, Forster, Julia, Ahmed, Daniel, Krepler, Katharina, Ansari-Shahrezaei, Siamak
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2021
Karger Publishers
Subjects
Blood vessels
Case Report
Case reports
Hemorrhage
Inflammation
intravitreal anti-vascular endothelial growth factor
Macular degeneration
Medical imaging
Monoclonal antibodies
Morphology
punctate inner choroidopathy
secondary choroidal neovascularization
Steroids
swept source-optical coherence tomography angiography
Intravitreal anti-vascular endothelial growth factor
Punctate inner choroidopathy
Secondary choroidal neovascularization
Swept source-optical coherence tomography angiography
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Summary:The purpose was to demonstrate the diagnostic and therapeutic feasibility of swept source-optical coherence tomography angiography (SS-OCTA) by picturing neovascular changes secondary to a rare white dot syndrome following long-term intravitreal ranibizumab (IVR). A 28-year-old Caucasian myopic female presented with visual loss in her right eye only. The clinical examination and multimodal imaging including spectral domain (SD)-OCT, blue-peak autofluorescence, fluorescein, and indocyanine green angiography (HRA Spectralis, Heidelberg Engineering; Heidelberg, Germany) as well as SS-OCTA (DRI Triton, Topcon; Tokyo, Japan) led to the diagnosis of idiopathic punctate inner choroidopathy with secondary subfoveal choroidal neovascularization (CNV). In addition to oral corticosteroids, a pro re nata regimen with IVR was initiated and guided by repeated SD-OCT and SS-OCTA. Six IVR were administered based on functional SS-OCTA en face scans illustrating vessel transformation and downsizing of the CNV area while SD-OCT B-scans were inconclusive as indirect signs of activity were absent throughout the follow-up period. SS-OCTA provided new possibilities for monitoring vessel development. IVR was managed based on vessel density as displayed by SS-OCTA.
ISSN:1663-2699
1663-2699
DOI:10.1159/000511669