Identification of Cancer Driver Genes by Integrating Multiomics Data with Graph Neural Networks

• Published in: Metabolites Vol. 13; no. 3; p. 339
• Main Authors: Song, Hongzhi, Yin, Chaoyi, Li, Zhuopeng, Feng, Ke, Cao, Yangkun, Gu, Yujie, Sun, Huiyan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.02.2023; MDPI
• Subjects: Biological analysis; biomarker; Cancer; cancer driver gene; Classification; Computer applications; Datasets; DNA methylation; Epigenetics; Gene expression; Genetic aspects; Genomes; graph neural network; Metabolism; Methods; multiomics data; Mutation; Neural networks; Oncology, Experimental; PPI network; Precision medicine; Transcriptomics; Tumors; China; cancer driver gene; PPI network; multiomics data; graph neural network; biomarker
• DOI: 10.3390/metabo13030339
• ISSN: 2218-1989

Cancer is a heterogeneous disease that is driven by the accumulation of both genetic and nongenetic alterations, so integrating multiomics data and extracting effective information from them is expected to be an effective way to predict cancer driver genes. In this paper, we first generate comprehensive instructive features for each gene from genomic, epigenomic, transcriptomic levels together with protein–protein interaction (PPI)-networks-derived attributes and then propose a novel semisupervised deep graph learning framework GGraphSAGE to predict cancer driver genes according to the impact of the alterations on a biological system. When applied to eight tumor types, experimental results suggest that GGraphSAGE outperforms several state-of-the-art computational methods for driver genes identification. Moreover, it broadens our current understanding of cancer driver genes from multiomics level and identifies driver genes specific to the tumor type rather than pan-cancer. We expect GGraphSAGE to open new avenues in precision medicine and even further predict drivers for other complex diseases.