Identification of the CART neuropeptide circuitry processing TMT-induced predator stress

• Published in: Psychoneuroendocrinology Vol. 50; pp. 194 - 208
• Main Authors: Sharma, Anju, Rale, Abhishek, Utturwar, Kaweri, Ghose, Aurnab, Subhedar, Nishikant
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.12.2014; Elsevier
• Subjects: 2,4,5-trimethyl-3-thiazoline (TMT); Amygdala; Animals; Antibodies, Neutralizing - administration & dosage; Bed nucleus of stria terminalis (BNST); Behavior, Animal - drug effects; Behavior, Animal - physiology; Behavioral psychophysiology; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Cocaine- and amphetamine-regulated transcript (CART); Cues; Endocrinology & Metabolism; Fear - drug effects; Fear - physiology; Fear response; Freezing Reaction, Cataleptic - drug effects; Freezing Reaction, Cataleptic - physiology; Fundamental and applied biological sciences. Psychology; Grooming; Hormones and behavior; Male; Nerve Tissue Proteins - metabolism; Neurons - drug effects; Neurons - metabolism; Odorants; Paraventricular nucleus (PVN); Predator stress; Proto-Oncogene Proteins c-fos - metabolism; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Sprague-Dawley; Thiazoles - pharmacology; Cocaine- and amphetamine-regulated transcript (CART); Amygdala; Predator stress; Bed nucleus of stria terminalis (BNST); Fear response; 2,4,5-trimethyl-3-thiazoline (TMT); Paraventricular nucleus (PVN); Affect affectivity; Cocaine amphetamine regulated transcript peptide; Central nervous system; Basal ganglion; Emotion emotionality; Identification; Paraventricular nucleus; Neuropeptide; Stress; Encephalon; Fear; Amygdaloid nucleus
• ISSN: 0306-4530; 1873-3360
• DOI: 10.1016/j.psyneuen.2014.08.019

Highlights • Identification of potential sites for CART-mediated modulation of fear processing. • CART in the central nucleus of amygdala is critical in fear processing. • CART transmits fear information to the ventral bed nucleus of stria terminalis. • CART in the paraventricular nucleus may process predator stress response. • CART in the olfactory system may not be involved in fear processing.