Homeostasis and Inflammation in the Intestine
The gut is home to our largest collection of microbes. The ability of the immune system to coevolve with the microbiota during postnatal life allows the host and microbiota to coexist in a mutually beneficial relationship. Failure to achieve or maintain equilibrium between a host and its microbiota...
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| Published in | Cell Vol. 140; no. 6; pp. 859 - 870 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
19.03.2010
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0092-8674 1097-4172 0020-7683 1097-4172 |
| DOI | 10.1016/j.cell.2010.01.023 |
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| Abstract | The gut is home to our largest collection of microbes. The ability of the immune system to coevolve with the microbiota during postnatal life allows the host and microbiota to coexist in a mutually beneficial relationship. Failure to achieve or maintain equilibrium between a host and its microbiota has negative consequences for both intestinal and systemic health. In this Review, we consider the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost. |
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| AbstractList | The gut is home to our largest collection of microbes. The ability of the immune system to co-evolve with the microbiota during postnatal life allows the host and microbiota to coexist in a mutually beneficial relationship. Failure to achieve or maintain an equilibrium between a host and its microbiota has negative consequences for both intestinal and systemic health. In this Review, we consider the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost. The gut is home to our largest collection of microbes. The ability of the immune system to coevolve with the microbiota during postnatal life allows the host and microbiota to coexist in a mutually beneficial relationship. Failure to achieve or maintain equilibrium between a host and its microbiota has negative consequences for both intestinal and systemic health. In this Review, we consider the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost.The gut is home to our largest collection of microbes. The ability of the immune system to coevolve with the microbiota during postnatal life allows the host and microbiota to coexist in a mutually beneficial relationship. Failure to achieve or maintain equilibrium between a host and its microbiota has negative consequences for both intestinal and systemic health. In this Review, we consider the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost. The gut is home to our largest collection of microbes. The ability of the immune system to coevolve with the microbiota during postnatal life allows the host and microbiota to coexist in a mutually beneficial relationship. Failure to achieve or maintain equilibrium between a host and its microbiota has negative consequences for both intestinal and systemic health. In this Review, we consider the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost. |
| Author | Glimcher, Laurie H. Gordon, Jeffrey I. Garrett, Wendy S. |
| AuthorAffiliation | 1 Department of Immunology and Infectious Diseases, Harvard School of Public Health 2 Department of Medicine, Harvard Medical School, Boston, MA 4 Ragon Institute of MGH/Harvard/MIT 3 Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO |
| AuthorAffiliation_xml | – name: 2 Department of Medicine, Harvard Medical School, Boston, MA – name: 1 Department of Immunology and Infectious Diseases, Harvard School of Public Health – name: 3 Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO – name: 4 Ragon Institute of MGH/Harvard/MIT |
| Author_xml | – sequence: 1 givenname: Wendy S. surname: Garrett fullname: Garrett, Wendy S. email: wgarrett@hsph.harvard.edu organization: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA – sequence: 2 givenname: Jeffrey I. surname: Gordon fullname: Gordon, Jeffrey I. organization: Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63108, USA – sequence: 3 givenname: Laurie H. surname: Glimcher fullname: Glimcher, Laurie H. email: lglimche@hsph.harvard.edu organization: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20303876$$D View this record in MEDLINE/PubMed |
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| Title | Homeostasis and Inflammation in the Intestine |
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