Homeostasis and Inflammation in the Intestine

The gut is home to our largest collection of microbes. The ability of the immune system to coevolve with the microbiota during postnatal life allows the host and microbiota to coexist in a mutually beneficial relationship. Failure to achieve or maintain equilibrium between a host and its microbiota...

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Bibliographic Details
Published inCell Vol. 140; no. 6; pp. 859 - 870
Main Authors Garrett, Wendy S., Gordon, Jeffrey I., Glimcher, Laurie H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 19.03.2010
Subjects
Animals
Biological Evolution
Cellular
Collection
Failure
Gastroenteritis - immunology
Gastroenteritis - physiopathology
Health
Homeostasis
Humans
Immune systems
Inflammatory Bowel Diseases - immunology
Inflammatory Bowel Diseases - microbiology
Intestinal Mucosa - immunology
Intestinal Mucosa - microbiology
Intestines
Intestines - cytology
Intestines - immunology
Intestines - microbiology
Intestines - physiology
Microorganisms
Probiotics
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ISSN0092-8674
1097-4172
0020-7683
1097-4172
DOI10.1016/j.cell.2010.01.023

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Summary:The gut is home to our largest collection of microbes. The ability of the immune system to coevolve with the microbiota during postnatal life allows the host and microbiota to coexist in a mutually beneficial relationship. Failure to achieve or maintain equilibrium between a host and its microbiota has negative consequences for both intestinal and systemic health. In this Review, we consider the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost.
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ISSN:0092-8674
1097-4172
0020-7683
1097-4172
DOI:10.1016/j.cell.2010.01.023