TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

• Published in: Journal of Virology Vol. 88; no. 2; pp. 1293 - 1307
• Main Authors: Heurich, Adeline, Hofmann-Winkler, Heike, Gierer, Stefanie, Liepold, Thomas, Jahn, Olaf, Pöhlmann, Stefan
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.01.2014
• Subjects: ADAM Proteins - genetics; ADAM Proteins - metabolism; ADAM17 Protein; Amino Acid Motifs; Cell Line; Humans; Peptidyl-Dipeptidase A - chemistry; Peptidyl-Dipeptidase A - genetics; Peptidyl-Dipeptidase A - metabolism; Protein Processing, Post-Translational; Proteolysis; Receptors, Virus - genetics; Receptors, Virus - metabolism; SARS coronavirus; SARS Virus - genetics; SARS Virus - physiology; Serine Endopeptidases - genetics; Serine Endopeptidases - metabolism; Severe Acute Respiratory Syndrome - enzymology; Severe Acute Respiratory Syndrome - genetics; Severe Acute Respiratory Syndrome - metabolism; Severe Acute Respiratory Syndrome - virology; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - metabolism; Virus Internalization; Virus-Cell Interactions
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.02202-13

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