Development of fast dispersible aceclofenac tablets: effect of functionality of superdisintegrants

• Published in: Indian journal of pharmaceutical sciences Vol. 70; no. 2; pp. 180 - 185
• Main Authors: Setty, C Mallikarjuna, Prasad, D V K, Gupta, V R M, Sa, B
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.03.2008; Medknow Publications & Media Pvt. Ltd; Medknow Publications
• Subjects: Care and treatment; Dosage and administration; Drug therapy; Nonsteroidal anti-inflammatory drugs; Pain; Pharmacology; Research Paper; Rheumatoid arthritis; India; aceclofenac; disintegration time; croscarmellose sodium; dissolution; sodium starch glycolate; Fast dispersible tablets; crospovidone
• ISSN: 0250-474X; 1998-3743
• DOI: 10.4103/0250-474x.41452

Aceclofenac, a non-steroidal antiinflammatory drug, is used for posttraumatic pain and rheumatoid arthritis. Aceclofenac fast-dispersible tablets have been prepared by direct compression method. Effect of superdisintegrants (such as, croscarmellose sodium, sodium starch glycolate and crospovidone) on wetting time, disintegration time, drug content, in vitro release and stability parameters has been studied. Disintegration time and dissolution parameters (t(50%) and t(80%)) decreased with increase in the level of croscarmellose sodium. Where as, disintegration time and dissolution parameters increased with increase in the level of sodium starch glycolate in tablets. However, the disintegration time values did not reflect in the dissolution parameter values of crospovidone tablets and release was dependent on the aggregate size in the dissolution medium. Stability studies indicated that tablets containing superdisintegrants were sensitive to high humidity conditions. It is concluded that fast-dispersible aceclofenac tablets could be prepared by direct compression using superdisintegrants.