Combination Therapy of Pembrolizumab plus Axitinib for a Patient on Hemodialysis with Metastatic Renal Cell Carcinoma: A Case Report

• Published in: Case reports in oncology Vol. 14; no. 3; pp. 1522 - 1529
• Main Authors: Katsumata, Yuki, Kawasaki, Yoshihide, Tanaka, Kayu, Nakayama, Daisuke, Katayama, Hiromichi, Shimada, Shuichi, Satake, Yohei, Sato, Takuma, Kawamorita, Naoki, Yamashita, Shinichi, Sato, Testuya, Shoji, Kosuke, Mitsuzuka, Koji, Ito, Akihiro
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 22.10.2021; Karger Publishers
• Subjects: axitinib; Blood pressure; Case Report; Case reports; Combination therapy; Creatinine; Drug dosages; Hemodialysis; Immunotherapy; Inhibitor drugs; Kidney cancer; Metastasis; Molecular weight; Monoclonal antibodies; Patient safety; pembrolizumab; renal cell carcinoma; Targeted cancer therapy; Axitinib; Pembrolizumab; Hemodialysis; Renal cell carcinoma
• ISSN: 1662-6575; 1662-6575
• DOI: 10.1159/000519855

Abstract Here, we discuss the safety and management of adverse events associated with pembrolizumab plus axitinib combination therapy for metastatic renal cell carcinoma in patients on hemodialysis. A 76-year-old man was diagnosed with cT3aN0M0 renal cell carcinoma due to gross hematuria. Stereoscopic radiotherapy for metastatic lesions of the ipsilateral kidney was performed 9 years after right laparoscopic radical nephrectomy. Soon after, the patient started to receive hemodialysis due to end-stage renal disease. Further stereoscopic radiotherapy was needed for metastasis of the ipsilateral kidney and lung. Fifteen years after diagnosis, systemic therapy was necessary to control new metastases, such as in the right scapular bone. We selected pembrolizumab plus axitinib combination therapy as the first-line systemic therapy for any risk as defined by the International Metastatic RCC Database Consortium. Although we needed to pay attention to the adverse events unique to hemodialysis, he underwent this combination therapy without any difficulty for 6 months. Here, we report the practice of combination therapy in patients on hemodialysis in light of the literature.