Role of Imaging in Diagnosis of a Rare Hepatosplenic Gamma Delta T-Cell Lymphoma during Pregnancy: A Case Report and Review of Literature

Hepatosplenic γδ T-cell lymphoma (HSTCL) is a very rare peripheral T-cell lymphoma characterized by extranodal infiltration of mature malignant post-thymic T-lymphocytes into sinusoids of the liver and spleen without lymphadenopathy and significant cytopenias. It is an aggressive form of lymphoma, r...

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Published inCase reports in oncology Vol. 12; no. 3; pp. 935 - 943
Main Authors Youssef, Reda R.H., Elmahdy, Amr, Kohla, Samah, Ibrahim, Feryal, Sabry, Ahmed Saied, Alobaidly, Amal, Saloum, Nehal
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.09.2019
Karger Publishers
Subjects
Abdomen
Biopsy
Blood
Bone marrow
Case Report
Case reports
Chemotherapy
Flow cytometry
Hematology
hstcl
Liver
Lymphoma
Medical diagnosis
Medical imaging
Medical prognosis
Pregnancy
Spleen
Tropical diseases
Tumors
Ultrasonic imaging
ultrasonography
Qatar
Pregnancy
Lymphoma
Ultrasonography
HSTCL
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Summary:Hepatosplenic γδ T-cell lymphoma (HSTCL) is a very rare peripheral T-cell lymphoma characterized by extranodal infiltration of mature malignant post-thymic T-lymphocytes into sinusoids of the liver and spleen without lymphadenopathy and significant cytopenias. It is an aggressive form of lymphoma, resistant to the conventional chemotherapy. We report a case of HSTCL in pregnancy. Because this condition is an extremely aggressive and rare entity, data from these cases can help confirm the most suitable treatment regimen and timing of initiation. The role of ultrasound and magnetic resonance imaging in the diagnosis has been discussed. HSTCL is a rare entity of T-cell lymphoma, uncommon in female patients and very rarely reported during pregnancy.
ISSN:1662-6575
1662-6575
DOI:10.1159/000504568