Does Madopar Have a Role in the Treatment of Prolonged Disorders of Consciousness? A Call for Randomized Controlled Trials

It is suggested that dopaminergic treatment may contribute to accelerated improvement in patients with a disorder of consciousness (DoC). Dopamine is an important stimulatory neurotransmitter, which plays a key role in alertness, arousal, behavior, emotion, cognition, and motor function. We discuss...

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Published inCase reports in neurology Vol. 13; no. 3; pp. 781 - 788
Main Authors Saleh, Christian, Andrykiewicz, Agnieszka, Hund-Georgiadis, Margret
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 16.12.2021
Karger Publishers
Subjects
Case reports
Case Series - General Neurology
clinical trials
disorders of consciousness
Dopamine
madopar
Magnetic resonance imaging
Medical imaging
Neurotransmitters
rehabilitation
Traumatic brain injury
Unconsciousness
Clinical trials
Madopar
Rehabilitation
Disorders of consciousness
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Summary:It is suggested that dopaminergic treatment may contribute to accelerated improvement in patients with a disorder of consciousness (DoC). Dopamine is an important stimulatory neurotransmitter, which plays a key role in alertness, arousal, behavior, emotion, cognition, and motor function. We discuss our experience with Madopar in 2 patients with DoC and review the literature on dopaminergic medication in patients with DoC.
ISSN:1662-680X
1662-680X
DOI:10.1159/000520435